When you open the event viewer on your machine, does it show any specific errors when you click the shortcut? You'll be able to find them under "administrative events".
More info about the event viewer for those who are not familiar:
You might need to explore further. See post here: https://answers.microsoft.com/en-us/windows/forum/all/kernelbasedll-is-causing-crash/111aa20b-b223-426a-b07d-7fe4daa01e46
Do note that this not seems the be a problem from Mendix but something on your system that is not working correctly.