JMS Connection- Messages are remaining in JMS queue with Unacknowledged status

Hi All, We are connected with JMS server (queue). We were getting messages continuously from JMS to our mendix application but suddenly we have got an issue of messages staying in JMS queue with ‘Unacknowledged' status and blocking next message in queue. Let us know possible reason for this or any of the such issue if you have faced.   Regards, Bharat 
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