The documentation on the AppStore says: "This module is meant to be used with Exchange servers with version 2007 and up."
Also, the underlying technology is Java Exchange Connector and their pages explicitly mention Exchange 2010 support. See 'Benefits' page at http://www.javaexchangeconnector.com/ This support has been there since 2009.
So, I would say yes. Maybe someone else has actual experience using it against Exchange. 2010